Breast cancer vaccine trials

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Breast cancer BC is a persistent global challenge for its high frequency in women although it seldom occurs in mendue to the large diffusion of risk factors and gene mutations, and for its peculiar biology and microenvironment. To date, BC can benefit from different therapeutic strategies involving surgery, ablation, chemotherapy, radiotherapy, and more specific approaches such as hormone therapy and the administration of various substances impairing cancer growth, aggressivity, and recurrence with different modalities. BC immunogenicity was latterly proven, so the whole immunotherapy field for BC is still at a very early stage.

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When Leisha Emens decided to specialize in treating breast cancer patients, her goal was to bring new ideas to the field. As a physician-scientist, Emens continually works on innovative strategies to beat one of the most common causes of cancer for women and a cancer that still takes far too many lives. The vaccine is injected under the skin and then it goes to work by drawing the attention of the immune cells, known as dendritic cells, to the vaccine injection site.

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Promising early results are in from a phase 1 clinical trial into the safety and efficacy of a new cancer vaccine. The new treatment is designed to stimulate the immune system into attacking certain cancers known to overexpress a specific protein. One of the more promising cancer biomarkers discovered in recent years has been a protein called HER2.

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A vaccine developed by Duke Cancer Institute researchers has shown early promise in targeting the HER2 protein that fuels a deadly form of breast cancer. In a phase 1 clinical trial that enrolled 22 women with recurrent cancers that overexpress the HER2 protein, the vaccine demonstrated an ability to halt tumor growth and improve survival for a subset of patients. A phase 2 trial is being planned at Duke. Kim Lyerly, M.

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Among 11 evaluable patients who had received more than the lowest dose of the vaccine, six 54 percent had clinical benefit. One patient with ovarian cancer had a complete response that lasted 89 weeks, one patient with gastroesophageal cancer had a partial response that lasted 16 weeks, and four patients two with colon cancer, one with prostate cancer, and one with ovarian cancer had stable disease. The patients' vaccines are individually customized by Berzofsky and colleagues using their own immune cells isolated from their blood.

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You may be offered the opportunity to take part in a clinical trial at some point during your treatment for breast cancer. Clinical trials are research studies that evaluate the safety and effectiveness of new treatment approaches for diseases. In some cases, a study may give you access to new therapies that are not yet readily available.

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Jump to navigation. For more information regarding our trials, please contact our Patient Coordinator Cancer immunology is an extremely new and exciting field.

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A preclinical study showing that a vaccination with a recombinant adenovirus expressing a truncated ErbB-2 antigen can cure advanced established murine breast cancer as well as extensive established metastatic lung cancer led to the launch of a small phase I study investigating a therapeutic cancer vaccine targeting HER2-expressing cancers. In this early clinical trial, the vaccine provided clinical benefit in several patients with metastatic HER2-positive cancers that had progressed on at least one line of standard therapy. The researchers enrolled patients with various metastatic HER2-positive cancers, including breast, ovarian, lung, colorectal, gastroesophageal, prostate, and bladder, among others, who had disease progression on treatment with at least one line of standard therapy.

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Allogeneic Tumor Cell Vaccine. All trials on the list are supported by NCI. Clinical trials look at new ways to prevent, detect, or treat disease.

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